A new peer-reviewed study published in the American Journal of Hypertension evaluates how well Aidee Health's cuffless, upper-arm blood pressure device follows blood pressure during the day, during sleep, and in the transition between the two, compared with conventional cuff-based 24-hour ambulatory blood pressure monitoring (ABPM).

Why the full 24 hours matter: blood pressure during sleep is a stronger predictor of cardiovascular events and mortality than daytime values, and people whose blood pressure does not fall sufficiently at night have increased cardiovascular risk. Capturing this requires measurements both day and night. Today that means repeated cuff inflations, which disturbs sleep during the night and is impractical during the day. Cuffless devices have so far struggled to estimate nighttime blood pressure accurately.

The study was led by Oslo University Hospital and included 50 adults aged 18–80, with and without medically treated hypertension. Participants wore the cuffless device on one upper arm and a validated cuff-based monitor (WatchBP O3) on the other arm for 24 hours of normal daily life. The cuffless device was calibrated once, immediately before the recording, at the same time point for all participants. The analysis followed the statistical approach of the European Society of Hypertension's 2023 Awake/Asleep test, with some methodological deviations described in the paper.

During daytime, the mean difference between the cuffless device and the reference was 2.0 (SD 6.2) mmHg for systolic and 2.3 (SD 5.3) mmHg for diastolic blood pressure. During sleep, the corresponding differences were 0.4 (SD 6.0) and 1.2 (SD 5.1) mmHg. For the main outcome, the change in blood pressure from day to night, the mean difference was 1.6 (SD 4.9) mmHg systolic and 1.2 (SD 4.0) mmHg diastolic, with correlation coefficients of 0.75 and 0.74 respectively.

The authors conclude that the device shows promise in tracking blood pressure across the 24-hour cycle, including the nocturnal dip, and that full validation is required before clinical use.

The study is part of the Hypersension 2.0 project, funded by the Research Council of Norway's User-driven Research-based Innovation programme (project 332371), a collaboration between Oslo University Hospital, the University of Oslo and Aidee Health.

Reference: Hove C, Seeberg TM, Bøtker-Rasmussen KG, Westgaard E, Heimark S, Waldum-Grevbo B, Larstorp ACK. Nocturnal blood pressure dipping in adults: a comparison between cuffless and ambulatory blood pressure monitoring. Am J Hypertens. 2026. https://doi.org/10.1093/ajh/hpag115 (open access)